TROP-2 Promotes Cell Proliferation via the AKT-Mediated PKC<b>α</b> Pathway and Is a Novel Target for Antibody-Drug Conjugates in Penile Carcinoma.

ABSTRACT:

Background

Current chemotherapy treatments, including the TIP (Taxol, Ifosfamide, Cisplatin) regimen, have shown limited effects but strong side effects in advanced Penile squamous cell carcinoma (PSCC) patients. Trophoblast cell-surface antigen-2 (TROP-2) is a novel target for antibody-drug conjugate (ADC) drugs and has been proven to be effective in several human cancers. This study aimed to explore the biological function and potential of the ADC target in PSCC cells.

Methods

A total of 196 PSCC tumor tissue specimens and clinicopathological data were collected. TROP-2 expression was detected by IHC, and the correlation between TROP-2 expression and the clinicopathological data of patients was analysed through statistical methods. Then, a series of in vivo and i

SUBMITTER: Tang Y 

PROVIDER: S-EPMC12712658 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature