A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study.

ABSTRACT: Physiological aging is accompanied by structural and molecular changes in the brain, with varying degrees in different brain areas, and is considered one of the major risk factors for neurodegenerative diseases. Thus, the present study focuses on elucidating age-related changes in the substantia nigra pars compacta (SNpc), a brain region particularly vulnerable in Parkinson's disease. Here, the aim is to gain a spatially resolved view of aging-dependent alterations to conclude early processes potentially involved in neurodegeneration. Neuromelanin granules and SNpc tissue are isolated from tissue samples of young and elderly individuals via laser microdissection and measured by mass spectrometry to ascertain changes in protein expression in response to age. The findings include the identif

SUBMITTER: Eggers B 

PROVIDER: S-EPMC12712771 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature