Targeted nanoparticles for placenta-specific drug delivery in pregnant rhesus macaques.

ABSTRACT: Rationale: To reduce the risks associated with systemic drug administration in pregnancy and create new therapies for placental dysfunction, we have previously developed targeted liposomes capable of selective delivery of payloads to the placentas of pregnant mice. In this study, we assessed whether these liposomes selectively accumulated in the placentas of nonhuman primates and evaluated the maternal systemic response to liposome infusion. Methods: Liposomes were produced using the thin-film method, decorated with the placental homing peptide CRGDKGPDC (iRGD) or non-targeting peptide ARALPSQRSR (ARA) and loaded with 5(6)carboxyfluorescein. Liposomes were infused intravenously into pregnant rhesus macaques early in gestation, at days 45-64 (iRGD, n = 4; ARA, n = 1) or mid-ge

SUBMITTER: Schmidt JK 

PROVIDER: S-EPMC12712799 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature