Nanoparticle retention enables non-invasive detection of metastases by magnetic particle imaging in murine breast cancer models.

ABSTRACT: Early detection of metastatic disease improves cancer survival, yet existing modalities are limited in their detection capabilities. We propose that magnetic particle imaging (MPI), an emerging technology, can be used for early detection of primary tumors and metastases. MPI detects minute quantities of magnetic particles that act as "cold tracers" which accumulate in areas of high immune activity. Methods: Pegylated Synomag® nanoparticles were intravenously injected into mouse models of breast cancer bearing primary tumors and spontaneously developed lung metastases. After 72 h, mice were subjected to three-dimensional MPI followed by structural imaging for co-registration. Non-tumor bearing mice served as controls for background signal correction and toxicity analysis. Animals wer

SUBMITTER: Korangath P 

PROVIDER: S-EPMC12712802 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature