Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis.

ABSTRACT:

Importance

Inflammation is increasingly implicated in the pathophysiology of mood and psychotic disorders. Integrating blood biomarkers and brain imaging may help uncover mechanistic pathways and guide targeted interventions.

Objective

To identify shared and distinct multivariate patterns of peripheral inflammation and gray matter volume (GMV) in early-stage depressive and psychotic disorders using a transdiagnostic machine learning approach.

Design, setting, and participants

The naturalistic multicenter PRONIA study was conducted between February 2014 and May 2019 with a follow-up period of up to 36 months; baseline data were analyzed between August 2021 and April 2024. Eight sites, including inpatient and outpatient facilities, in 5 European countries (Germany, Ital

SUBMITTER: Popovic D 

PROVIDER: S-EPMC12712837 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature