Inferring Cell Differentiation Dynamics with Unobserved Progenitors.

ABSTRACT: A cell differentiation map describes the transitions between cell types during a developmental process, and determining this map is a key challenge in developmental biology. Recent single-cell lineage tracing technologies generate lineage trees that describe the history of cell divisions during a developmental process but do not directly measure differentiation events between cell types. Current approaches to infer cell differentiation maps from cell lineage trees make unrealistic assumptions about the developmental process, do not allow for unobserved progenitor cell types, or do not infer cell-type specific rates of growth and transitions. To address these issues, we introduce TROUPE, a likelihood-based framework that infers differentiation and growth dynamics directly from leaf-labeled

SUBMITTER: Howard-Snyder W 

PROVIDER: S-EPMC12712906 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature