A bifunctional optical reporter for tracking estrogen response dynamics in neurons.

ABSTRACT: Estrogens are inherently dynamic signaling molecules whose fluctuations induce profound shifts in physiology and behavior. However, methods for tracking the dynamics of estrogen action in vivo are limited and not tissue-specific, making it difficult to directly relate dynamics to ongoing physiological, behavioral, and neural changes. Traditionally, estrogen sensitive cells have been identified by metrics such as receptor expression or radioactive ligand binding, but these measures do not capture the dynamic nature of hormone response. In addition, current methods for assessing the dynamics of estrogens in an individual, including microdialysis and vaginal cytology, lack temporal and spatial resolution. To address this need we developed a bifunctional reporter called neuro-seeER (neu

SUBMITTER: Cara AL 

PROVIDER: S-EPMC12712938 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature