Profiles of Aging Based on Cognition, Affect, and Brain Reserve.

ABSTRACT: The aging paradox describes improvements in emotional wellbeing as a function of aging, despite declines in cognition. Conversely, late life depression has been associated with increased cognitive decline in aging. We sought to understand these seemingly contradictory patterns of cognitive and mental health in older age. Building on cognitive reserve, affective reserve, and brain reserve models of aging, we developed three alternative algorithmic approaches to group N=22,686 participants from the UK Biobank into different profiles of aging. Our results revealed that aging profiles identified using our data-driven brain reserve model, which incorporated measures of cognition, neuroticism, and brain volume, achieved the highest validation results. Importantly, only two of the four aging prof

SUBMITTER: Jarukasemkit S 

PROVIDER: S-EPMC12712940 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature