Autophagy-Targeting Fe-Cu Nanozyme for Tumor Immune Microenvironment Remodeling and Image-Guided Cancer Immunotherapy.

ABSTRACT: The suppressive tumor immune microenvironment (TIME) is a critical driver of tumor progression, immune evasion, and therapy resistance. Despite the transformative potential of immunotherapy, autophagy within the TIME weakens immune surveillance by downregulating tumor cell surface major histocompatibility complex class I (MHC-I) expression, thereby facilitating immune escape. Here, a novel nanozyme-based strategy is reported to modulate autophagy and restore anti-tumor immunity. Iron-copper metal-organic frameworks (Fe-Cu MOFs) are engineered with tunable peroxidase, glutathione peroxidase, and oxidase-like activities, and an optimal Fe:Cu ratio that confers potent redox activity alongside robust inhibition of autophagic flux is identified. These MOF nanozymes selectively impair autophagy

SUBMITTER: Yan L 

PROVIDER: S-EPMC12713008 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature