3D Membrane Microstructures for Increased Efficiency in Blood-Gas Transfer.

ABSTRACT: Treating severe lung diseases with extracorporeal membrane oxygenation (ECMO) is often accompanied by serious complications, restricting applicability and adversely affecting outcomes. Membrane oxygenators, based on hollow fiber membranes (HFM), are a central ECMO component. Here, current designs are reaching their limits regarding hemocompatibility and gas transfer efficiency. Three-dimensional structures, based on triply periodic minimal surfaces, can provide superior hemodynamics. However, previous 3D membrane structures don't provide the required channel scale and gas transfer performance. In this study, we have fabricated 3D microstructures and tested them in vitro against state-of-the-art HFM. The 3D structure provided gas transfer coefficients within 50 and 45% of the HFM's value fo

SUBMITTER: Barbian KP 

PROVIDER: S-EPMC12713010 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature