Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders.

ABSTRACT: G1 to S phase transition protein (GSPT1), a small GTPase involved in translation termination, which promotes the progression of cancer cells, has emerged as an attractive potential therapeutic target for cancer treatment with the rapid breakthrough of molecular glue degraders (MGDs). Although the precise mechanism of GSPT1 in cancer biology is partially understood, in this review, the characteristics of GSPT1 expression and regulatory networks are systematically attempted to be addressed, from insights into the structure, expression, and molecular mechanisms, highlighting the distribution and isoform-specific signaling of GSPT1 in tumors. The clinical significance is emphasized, immune interactions, and oncogenic pathways of GSPT1-targeted therapies, proposing strategies to address current

SUBMITTER: Lin Q 

PROVIDER: S-EPMC12713026 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature