Gene Editing of a Susceptibility LncRNA Enhances Broad-Spectrum Disease Resistance in Rice without Developmental Trade-Offs.

ABSTRACT: The identification and genomic editing of defense-related genes to confer resistance to pathogens is an effective and promising strategy for use in crop breeding. However, resistance is often associated with growth inhibition, a phenomenon referred to as the "trade-off" effect, making enhancing resistance without sacrificing yield challenging. In this study, a novel strategy is presented to enhance broad-spectrum resistance in crops without yield loss by editing susceptibility lncRNAs. RESIS, a pathogen-induced lncRNA that acquired its function in the pathogen response during domestication, is identified. Upon pathogen invasion, RESIS is activated by effector-binding elements on its promoter and subsequently binds to NAA15 and NAA10, two core components of the NatA complex. RESIS enables N

SUBMITTER: Zhao WL 

PROVIDER: S-EPMC12713027 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature