Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells.

ABSTRACT: Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which this occurs is not as yet fully understood. Contrary to prevalent thought that the relay of extracellular cues to the nucleus to effect its fate and function predominantly relies on direct transmission through the cytoskeletal structure, we demonstrate through the use of high frequency (10 MHz) nanomechanostimulation that induced fluctuations of the cells' nuclear chromatin response are primarily influenced by the spatiotemporal dynamics associated with the bidirectional crosstalk between two key second messengers, namely calcium (Ca²⁺) and cyclic adenosine monophosphate (cAMP). In par

SUBMITTER: Ambattu LA 

PROVIDER: S-EPMC12713034 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature