Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis.

ABSTRACT: Selenium supplementation has potential in treating aging-related disorders like neurodegenerative and cardiovascular diseases, but its use is limited by poor bioavailability, a narrow therapeutic window, and unclear mechanisms. To overcome this, redox-dual-responsive diselenide-bridged mesoporous silica nanoparticles (SeMSNs) are developed. SeMSNs effectively reduce oxidative stress and downregulate senescence markers (p16, p21), suppressing senescence in both naturally aged primary mouse embryonic fibroblasts (MEFs) and H₂O₂-induced HEK-293T cells. They show prolonged antioxidant effects (p < 0.05) and lower cytotoxicity (p < 0.01) than commercial selenomethionine. In aged mice, SeMSNs extend lifespan, reduce frailty, and improve age-related conditions, including mus

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12713047 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature