Acidogenesis-Propelled Coordination Transition in Light-Triggered Fe-Polyphenol Polymer for Reactive Oxygen Species-Augmented Antitumor Therapy.

ABSTRACT: Iron-based Fenton agents have emerged as promising candidates for tumor therapy due to its excellent selectivity, yet their therapeutic potential is substantially constrained by inefficient Fe³⁺/Fe²⁺ conversion in the tumor microenvironment. Herein, based on a coordination engineering strategy, a light-responsive Fe-polyphenol coordination polymer (FeBPs), integrating Fe centers, Bodipy-based photoacid generators, and PEG-stabilized polyphenol ligands, is designed to explore how to accelerate the transformation efficiency of Fe³⁺ to Fe²⁺ by incorporating both internal and external factors. In terms of internal factors, upon irradiation at 630 nm, the FeBPs trigger the exposure of catalytic sites derived from the coordination transition nature of

SUBMITTER: Wan Y 

PROVIDER: S-EPMC12713086 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature