Hyaluronic Acid Hydrogel Implants for Sustained Release of Oxaliplatin and Resiquimod to Prevent Hepatocellular Carcinoma Recurrence Post-Radiofrequency Ablation.

ABSTRACT: Hepatocellular carcinoma (HCC) remains a global challenge due to limited therapies and high recurrence. While radiofrequency ablation (RFA) is commonly used, its efficacy is hindered by incomplete ablation. Local immunotherapy has gained attention as a novel strategy to improve therapeutic efficacy through targeted activation of anti-tumor immunity. In this work, a biopolymer implant (BI) hydrogel based on hyaluronic acid is developed for the sustained release of oxaliplatin (OXA) and resiquimod (R848), aiming to enhance the immunotherapeutic efficacy of RFA in liver cancer. The injectable BI hydrogel, formed via Schiff base linkage, enables prolonged drug release and exhibits favorable biosafety. In subcutaneous HCC models, RFA + BI(OXA + R848) achieved 97.1% tumor inhibition and 40% comp

SUBMITTER: Shan Y 

PROVIDER: S-EPMC12713106 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature