Laser Ultrasound Super-Resolution Imaging for Multi-Parametric Non-Invasive Volumetric Characterization of Brain Cancer.

ABSTRACT: Accurate characterization of brain tumor heterogeneities and microvascular dynamics remains an unmet need in cancer research driving the development of innovative imaging methods. Here, laser ultrasound super-resolution imaging (LUSSI) is introduced, a hybrid modality combining laser-generated ultrasound with optoacoustic (OA) contrast to enable functional volumetric (3D) super-resolution imaging of vascular structures in vivo. The system integrates a laser ultrasound (LUS) emitter and a spherical array transducer to localize microbubble responses in 3D, further enabling concurrent acquisition of multi-spectral (multi-wavelength) OA data. The capabilities of LUSSI to assess tumor heterogeneities are demonstrated in a murine glioblastoma model, including visualization of intra-tumoral vascu

SUBMITTER: Nozdriukhin D 

PROVIDER: S-EPMC12713108 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature