The LIBRA index of modifiable risk factors for mild cognitive impairment and dementia in a late-life population-based cohort study.

ABSTRACT: The Lifestyle for Brain Health (LIBRA) index, a weighted measure of modifiable risk factors for dementia, has been widely applied in European cohorts but less explored in US populations. We applied it to a cohort aged 65+ years, sampled from a relatively low-socioeconomic US region, and compared its predictive validity for incident mild cognitive impairment (MCI) and incident dementia risk. We used both reference factor weights derived from published meta-analyses and cluster-specific factor weights based on estimation results using our own cohort data. We also compared the original LIBRA index with an updated version (LIBRA2), which added three new risk factors including hearing impairment, sleep disturbance, and low social contact. We used joint modeling to account for informative attrit

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12713165 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature