Effectiveness of different antibiotic lock solutions on catheter-related infections of hemodialysis patients: a systematic review and meta-analysis.

ABSTRACT:

Background

Antibiotic lock therapy (ALT) delivers high-concentration antimicrobials into catheter lumens and has been proposed to prevent infections in hemodialysis (HD) patients.

Methods

We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) and quasi-experimental studies comparing ALT with non-antibiotic or no-lock solutions in adults on HD. Six databases (PubMed, Embase, Scopus, Web of Science, Cochrane CENTRAL, CINAHL) were searched through 27 June 2025, identifying 17 studies involving 3,482 catheters. Two independent reviewers extracted data and assessed bias using the Cochrane RoB 2. Random-effects models yielded pooled risk ratios (RR) and incidence rate ratios (IRR) with 95% confidence intervals (CI).

Results

ALT reduced cathe

SUBMITTER: Sarmadi S 

PROVIDER: S-EPMC12713221 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature