Molecular surveillance of antimalarial drug resistance genes in Nigeria: a systematic review and roadmap to malaria elimination.

ABSTRACT:

Background

Malaria remains a significant public health challenge in Nigeria, accounting for a substantial proportion of global malaria cases and deaths. Although artemisinin-based combination therapies (ACTs) are the recommended first-line treatments, resistance to antimalarial drugs continues to threaten malaria control efforts. This systematic review provides an overview of the molecular surveillance of antimalarial drug resistance in Nigeria, aiming to identify prevalent resistance markers and inform future research and policy directions.

Methods

A systematic search was conducted using databases including PubMed, ScienceDirect, Ovid and Scopus. Studies published from 2010 to 2024 and focused on key resistance markers such as Pfcrt, Pfmdr, Pfdhfr, Pfdhps, and Pfk13 genes w

SUBMITTER: Bamikole OJ 

PROVIDER: S-EPMC12713234 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature