Establishment of non-invasive diagnostic prediction model for HIV-positive asymptomatic neurosyphilis patients.

ABSTRACT:

Background

Although guidelines strongly recommended universal screening for neurosyphilis (NS) in people living with HIV (PLWH), the invasiveness of lumbar puncture (LP) made comprehensive screening difficult, particularly among asymptomatic individuals, increasing the risk of missed diagnoses. Because of the common transmission routes, the co-infection rate of PLWH and syphilis was extremely high. Establishing effective diagnostic and predictive models for NS was essential to improve diagnostic accuracy and timeliness. This study aimed to develop a non-invasive method for detecting asymptomatic neurosyphilis (ANS) in PLWH.

Methods

This study included HIV patients hospitalized at the Second Hospital of Nanjing from January 2013 to September 2024 who tested positive for syphi

SUBMITTER: Guan H 

PROVIDER: S-EPMC12713297 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature