Defining the interactome of the pancreas-specific SPCA2 isoform (SPCA2C) identifies unique links to store-operated Ca²⁺ entry.

ABSTRACT: Calcium (Ca²⁺) is critical for normal cell function, and several protein networks are required for Ca²⁺ signaling. In the pancreas, regulated changes in cytosolic Ca²⁺ allow for the exocytosis of zymogen granules, and altered Ca²⁺ signaling underlies pancreatic pathologies. Previously, our laboratory showed a pancreas-specific isoform of secretory pathway Ca²⁺-ATPase 2 (also known as calcium-transporting ATPase type 2C member 2; SPCA2), termed SPCA2C (gene name Atp2c2c, C-terminally truncated form), affects multiple pathways involved in Ca²⁺ homeostasis. The goal of this study was to define the SPCA2C interactome that contributes to these processes. Using proximity-dependent biotin identification, BioID, we expressed SPCA2C-

SUBMITTER: Samardzija P 

PROVIDER: S-EPMC12713332 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature