Supramolecular self-assemblies of Ru(II) phototherapeutics: biological activity of micro- and nano-particles acting as reservoirs.

ABSTRACT: Ruthenium(II) coordination complexes have many appealing properties as prodrugs, but can suffer from poor aqueous solubility and short circulation times, drastically decreasing efficiency in vivo. Nanoformulations using a variety of carriers, such as inclusion in polymers/lipids or adsorption on inorganic nanoparticles have been applied to overcome this limitation, but unfortunately, these approaches raise additional concerns regarding the fate of the carriers, with potential long-term toxicity and accumulation in vital organs. Here, we present an alternative delivery strategy with formation of pure and polymer-supported supramolecular self-assemblies of Ru(II) complexes acting as "reservoirs". A facile preparation of size-controlled particles was achieved using a controlled precipi

SUBMITTER: Laisney J 

PROVIDER: S-EPMC12713340 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature