Depletion of CD169⁺ border-associated macrophages induces Parkinson's disease-like behavior.

ABSTRACT: Parkinson's disease (PD) and Alzheimer's disease (AD) present with complex behavioral symptoms that can arise in the absence of overt structural brain damage. Recent evidence suggests that border-associated macrophages (BAMs) located at the brain's interfaces regulate central nervous system function, yet the specific roles of distinct BAM subsets remain largely undefined. By reanalyzing single-nucleus RNA sequencing data from postmortem PD brains, we identified a BAM subset expressing CD169 that was significantly reduced in patients compared with controls. To examine their function, we employed CD169-DTR mice to selectively ablate CD169⁺ BAMs and evaluated behavioral and histological changes. Depletion of CD169⁺ BAMs induced tremors, abnormal hindlimb reflexes, and he

SUBMITTER: Ohki T 

PROVIDER: S-EPMC12713354 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature