Development of a prognostic model related to mitochondria and programmed cell death-related genes in bladder cancer.

ABSTRACT:

Background

Various forms of programmed cell death (PCD) play a crucial role in regulating the development and spread of cancer, with mitochondria serving as key organelles involved in executing PCD. In this study, mitochondrial and PCD-related prognostic genes in bladder cancer (BLCA) were explored, and prognostic models were constructed.

Methods

The GSE32894, GSE13507, and The Cancer Genome Atlas (TCGA)-BLCA datasets related to BLCA were retrieved. The intersection genes of differentially expressed genes (DEGs) between BLCA and control samples in TCGA-BLCA, mitochondrial-related genes (MRGs), and PCD-related genes (PCD-RGs) were obtained for univariate and multivariate Cox regression analysis. Prognostic genes were selected, and a prognostic model was developed. Then, the v

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12713357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature