ArgT functions as an arginine transporter in <i>Staphylococcus aureus</i>.

ABSTRACT: Glycolytic activity is required for Staphylococcus aureus (S. aureus) to establish an infection. These data indicate that carbon catabolite repression, mediated by CcpA, is active during the initial stages of infection. CcpA represses both the biosynthesis and catabolism of arginine; therefore, it is hypothesized that arginine must be transported by S. aureus from host tissue to facilitate growth during the establishment of an infection. Within S. aureus USA300, two known arginine/ornithine antiporters, ArcD1 and ArcD2, are encoded on the two copies of the arginine deiminase operon (native and arginine catabolite mobile genetic element-derived). However, when both antiporters are inactivated via allelic replacement, no growth defect is observed in defined medium

SUBMITTER: Schulze GF 

PROVIDER: S-EPMC12713382 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature