Effect of Squalane as a Carrier in O/W Nanoemulsions for Dermal Delivery of Vitamin E.

ABSTRACT: Vitamin E, a potent antioxidant, is widely used in cosmetics to combat skin aging, but its lipophilic nature poses challenges for dermal delivery. Squalane, a biocompatible carrier, may enhance the stability and skin permeation of vitamin E in oil-in-water (O/W) nanoemulsions. O/W nanoemulsions containing vitamin E were formulated using high shear homogenization with varying coconut oil-to-squalane ratios (0:3, 1:2, 2:1, 3:0). Physicochemical properties (particle size, polydispersity index, ζ-potential, pH, conductivity) were characterized. In vitro release kinetics were assessed via dialysis, quantified by HPLC, and skin permeation was evaluated using Franz diffusion cells with porcine ear skin. Nanoemulsions exhibited hydrodynamic diameters of 107.67 ± 7.57 to 134.38 ± 3.15 nm, polydispe

SUBMITTER: de Souza AC 

PROVIDER: S-EPMC12713435 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature