Antimicrobial Peptide-Loaded Mesoporous Silica Nanoparticles: A pH-Triggered Controlled Release against Biofilms.

ABSTRACT: The rapid emergence of multidrug-resistant bacteria has intensified interest in antimicrobial peptides (AMPs) as alternative therapeutics due to their potent broad-spectrum activity and low propensity for inducing resistance. However, the clinical translation of AMPs is hindered by their inherent low stability and susceptibility to proteolytic degradation. In this study, we investigated a pH-responsive delivery system using mesoporous silica nanoparticles (MSNs) to encapsulate frog-derived temporin B and scorpion-derived BmKn2two AMPs that have shown particular promiseaiming to enhance their stability and enable targeted eradication of Staphylococcus aureus biofilms. AMPs were efficiently adsorbed onto MSNs via electrostatic interactions, achieving a high loading capacity. The rel

SUBMITTER: Sakaj M 

PROVIDER: S-EPMC12713444 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature