Design and Synthesis of Novel Chalcone Derivatives Targeting Bladder and Liver Cancer: Cytotoxicity Evaluation and Preliminary Mechanistic Studies.

ABSTRACT: The high incidence and mortality rates of bladder and liver cancers, combined with the challenges of early diagnosis, contribute to significant strain on healthcare systems. Standard chemotherapy treatments, which commonly use drug combinations, often cause intense side effects, reducing patient compliance and limiting therapeutic success. Considering the promising activity of a chalcone derivative of 2-methoxy-4-propylphenol against HepG2 cancer cells (hit compound 1), discovered recently by our group, we synthesized new chalcone derivatives of this hit compound with three structural patterns to try to increase its activity, selectivity, and spectrum of action against other tumor lineages. Among the 12 new chalcones obtained, the O-methylated derivative 3 was the most

SUBMITTER: Hermenegildo AM 

PROVIDER: S-EPMC12713470 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature