Silver-Mediated Electrosynthesis of Substituted Isoquinolines via Cyclization of 2‑Ethynylbenzaldehydes.

ABSTRACT: The electrosynthesis of substituted isoquinolines via silver-mediated intramolecular cyclization of 2-ethynylbenzaldehydes with ammonium acetate is presented. The reaction employs Ag-(+)|C(-) electrodes in a DMF/isopropanol mixture at 60 °C using LiClO₄ as the supporting electrolyte, affording isoquinoline derivatives in yields up to 76%. Control experiments and DFT calculations were conducted to support a plausible reaction mechanism.

SUBMITTER: de Borba ES 

PROVIDER: S-EPMC12713483 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature