IL-13 Modulates Antiviral Effector and Proinflammatory Pathways in Rhinovirus-Infected Pediatric Bronchial Epithelium.

ABSTRACT:

Background

Rhinovirus (RV) is the most common trigger of viral-induced pediatric asthma exacerbations. The impact of IL-13-driven inflammation, common in pediatric asthma, on airway epithelial antiviral and inflammatory responses to RV remain unclear.

Objective

Determine how IL-13-driven T2 inflammation modulates pediatric bronchial epithelial cell responses to RV infection.

Methods

Bronchial epithelial cells (BECs) were collected from children with (n=50) and without (n=11) asthma. They were differentiated at an air-liquid interface for 21 days, pretreated with IL-13 (10ng/mL) for 7 days to model T2 inflammation, then infected with RV-A16 (MOI 0.5). RNA sequencing of BECs was performed prior to and on days 2, 4, 7, and 10 post infection. Linear and generalized additi

SUBMITTER: Dela Cruz PC 

PROVIDER: S-EPMC12713584 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature