Kupyaphores─Self-Assembling Diisocyanolipopeptide Zn^II Ionophores in <i>Mycobacterium tuberculosis</i> Zn^II/Cu^I/II Homeostasis and Antibacterial Effects.

ABSTRACT: Mycobacterium tuberculosis (Mtb), the leading cause of infectious disease mortality from a single pathogen, requires essential metal ions to establish infection and persist in the host. Kupyaphores, a suite of recently identified amphiphilic diisocyanolipopeptides, were reported to assist with Zn^II acquisition to support a multitude of Zn^II-dependent metalloenzymes critical for Mtb's survival and pathogenicity. However, compared to well-studied Fe^III acquisition systems in Mtb, the mechanisms for Zn^II acquisition and homeostasis remain virtually unexplored. Herein, we reveal them as novel metal ionophores in Mtb's metal-fluctuating lipidic niche. A concise modular scalable synthesis was developed to assess the c

SUBMITTER: Wong TY 

PROVIDER: S-EPMC12713621 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature