Cardioprotective role of RBFox1 in myocardial infarction-induced heart failure.

ABSTRACT:

Aims

Alternative mRNA splicing is a significant part of transcriptome reprogramming during the pathological manifestation of heart diseases. Earlier studies have identified a muscle-specific isoform of RBFox1 (RNA binding fox-1 homolog 1) to be a key RNA splicing regulator in pressure overload induced heart failure. However, the physiological impact of RBFox1 in myocardial infarction (MI), and the downstream mRNA alternative splicing events during MI induced cardiac remodelling remains unknown.

Methods and results

Here we found RBFox1 expression was significantly decreased in Sprague-Dawley rat hearts post MI. Restoring the expression of RBFox1 prevented cardiac remodelling and dysfunction post MI characterized by improved cardiac function, reduced hypertrophy and fibrosis,

SUBMITTER: He M 

PROVIDER: S-EPMC12713644 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature