Striatal ensembles specify and control granular forelimb actions.

ABSTRACT: The ability of the brain to control specific fine actions is crucial for survival. The striatum is a critical brain center for both movement and learning, and its dysfunction underlies numerous movement disorders^1-9. Whereas activity in the striatum has been classically viewed as invigorating^5,10-13 and reinforcing movements^12-20, recent studies suggest that striatal activity encodes specific movements^21-24. However, it is not known how granular this activity is, and if it indeed controls specific ongoing movements. We designed a task where mice performed two minimally-different forelimb actions, consisting of a push or pull isometric force on an immobile joystick, and imaged the activity of medium spiny neurons (MSNs) in the dorsolateral striatu

SUBMITTER: Rodrigues-Vaz I 

PROVIDER: S-EPMC12713657 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature