Agonism of mosquito and human transient receptor potential ankyrin 1 (TRPA1) channels by the natural drimane sesquiterpene cinnamodial.

ABSTRACT: TRPA1 channels are multi-modal receptors in animals for sensing noxious physical and chemical factors. They are considered promising biochemical targets for developing repellents of arthropod disease vectors and drugs to treat a variety of medical conditions including pain, inflammation, and itch. Recently, we discovered that cinnamodial (CDIAL), a natural drimane sesquiterpene produced by the medicinal plant Cinnamosma fragrans, agonizes mosquito TRPA1 channels and is antifeedant and repellent to Aedes aegypti. However, the selectivity of CDIAL for mosquito vs. human TRPA1 and how CDIAL binds to TRPA1 channels are unknown. Here we characterize the agonism by CDIAL of Aedes aegypti (Aa) and Homo sapiens (Hs) TRPA1 channels and compare it to that induced by two o

SUBMITTER: Lee T 

PROVIDER: S-EPMC12713677 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature