<i>CD36</i> and <i>SR-B1</i> polymorphisms exhibit distinct association patterns in active and latent tuberculosis.

ABSTRACT: Introduction. Host genetics plays a pivotal role in determining disease susceptibility among individuals infected with Mycobacterium tuberculosis. Scavenger receptors (SRs) such as CD36 and SR-B1 mediate pathogen recognition and lipid uptake, both of which are central to mycobacterial entry and immune modulation.Gap Statement. Polymorphisms rs1761667 and rs3211938 in CD36 and rs4238001 in SR-B1 have not been investigated in any population in relation to both latent tuberculosis infection (LTBI) and active tuberculosis (TB).Aim. To genotype CD36 and SR-B1 polymorphisms and evaluate their association with TB and LTBI. To predict the functional/regulatory impact of these SNPs and compare their allele frequencies with global

SUBMITTER: Tariq EB 

PROVIDER: S-EPMC12713683 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature