Animal modelling with the <i>Francisella tularensis</i> subspecies <i>holarctica</i> strain OR96-0246.

ABSTRACT: Tularemia is a zoonotic disease caused by Francisella tularensis. Most human cases are caused by F. tularensis ssp. tularensis (type A) or F. tularensis ssp. holarctica (type B), with the former considered more virulent. For this reason, type A isolates are often the benchmark for the testing of new vaccines or antibiotics. However, both subspecies cause considerable disease and can differ in their responsiveness to medical countermeasures. Accordingly, there is a need to identify and characterize representative type B isolates that are available to qualified research institutions to ensure the development of future vaccines or antibiotics is efficacious against both subspecies. The type B isolate OR96-0246 was identified as a strain that can address this

SUBMITTER: Mlynek KD 

PROVIDER: S-EPMC12713684 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature