Factors Predicting the Efficacy of Valbenazine and Exacerbation of Tardive Dyskinesia After Valbenazine Discontinuation in Japanese Patients: A Post Hoc Analysis of the J-KINECT Study.

ABSTRACT:

Purpose

To identify factors affecting valbenazine efficacy and change in tardive dyskinesia (TD) symptoms after valbenazine discontinuation using post hoc analysis of the J-KINECT study evaluating valbenazine efficacy and safety in patients with TD.

Methods

J-KINECT comprised a 6-week, placebo-controlled, double-blind period; a 42-week valbenazine extension period; and a 4-week follow-up period. Predictors for valbenazine efficacy were analyzed using multiple regression analysis for change in Abnormal Involuntary Movement Scale (AIMS) total score and logistic regression analysis for ≥50% improvement in AIMS total score, from baseline to week 6. For factors predicting changes in TD symptoms after valbenazine discontinuation, multiple regression analysis examined the change in

SUBMITTER: Watanabe Y 

PROVIDER: S-EPMC12713690 | biostudies-literature | 2026 Jan-Feb 01

REPOSITORIES: biostudies-literature