Early life sleep is associated with longevity in <i>Drosophila</i>.

ABSTRACT: Sleep is a universal behavior that is critical for brain function and physiological homeostasis. While growing epidemiological and experimental evidence suggests reduced sleep quality is associated with negative health outcomes, the causal relationship between sleep loss and reduced longevity remains poorly understood. Here, we examine sleep across the lifespan and its relationship to longevity in Drosophila melanogaster. We examined the associations between numerous components of sleep at different life stages to longevity. Early life sleep, but not middle and late-life sleep, was positively associated with longevity. Age-dependent changes in sleep were consistent but accelerated, when flies are housed under stressful conditions including nutrient and temperature stress. Further, p

SUBMITTER: Yeragi E 

PROVIDER: S-EPMC12713745 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature