Integrating Monitoring and Biomonitoring Data with Mechanistic Models to Better Estimate and Characterize Aggregate Human Exposures to Semivolatile Organic Chemicals.

ABSTRACT: Humans are exposed to many chemicals from multiple sources through various pathways. Many semivolatile organic chemicals (SVOCs) are ubiquitous in indoor environments, but the extent of exposure and relative importance of different pathways (near-field or far-field) are uncertain. Here, 37 SVOCs with measured concentrations in indoor media are used in conjunction with a mass balance indoor fate, exposure, and toxicokinetic model to 1) estimate exposures from indoor environments, 2) incorporate measured dietary (far-field) exposures, 3) evaluate modeled biological concentrations in blood and urine against previously published human biomonitoring (HBM) estimates, 4) calculate the relative importance of different exposure pathways, and 5) demonstrate the value of using models and monitoring d

SUBMITTER: Hughes L 

PROVIDER: S-EPMC12713766 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature