Particulate Matter Exposure and Progression Trajectories of Cardiovascular Disease, Mood Disorders, Comorbidity, and Mortality: Associations and Underlying Metabolic Mechanisms.

ABSTRACT: The role of particulate matter (PM) in the bidirectional relationship between cardiovascular disease (CVD) and mood disorders remains unclear. This UK Biobank-based study included participants without prior CVD or mood disorders at baseline with complete data. Outcomes included CVD and mood disorder incidences, comorbidity, and mortality. During a median 13.8-year follow-up, among 358,119 participants, 145,406 developed CVD, 27,318 mood disorders, 15,443 comorbidity, and 26,703 deaths. Multistate analysis showed PM_2.5 exposure significantly increased risks of progression in both trajectories. For trajectory 1, each IQR increase in PM_2.5 was associated with HRs (95% CI) of 1.219 (1.216-1.222), 1.080 (1.070-1.091), and 1.033 (1.013-1.053) for progression from baseline t

SUBMITTER: Hu C 

PROVIDER: S-EPMC12713789 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature