Obstructive sleep apnea mouth breathing phenotype response to combination oral appliance therapy.

ABSTRACT:

Introduction

Obstructive sleep apnea (OSA) is a multisystem physiological disorder of breathing during sleep that may contribute to systemic physiological imbalances and can also be exacerbated by the use of some commonly prescribed medications.

Methods

In a randomized parallel design trial, we included phenotypic mild to severe OSA mouth-breathing subjects (n = 36) confirmed by home polygraphy, to evaluate the efficacy of oral appliance plus mouth shield and oral appliance only during sleep on night 1 (T1) after 4 weeks (T2), and after 8 weeks (T3) of oral appliance therapy. Respiratory dynamics data were collected. Primary outcomes were respiratory event index and mouth breathing. Anamnesis on medication intake was collected at enrollment.

Results

The respira

SUBMITTER: Schramm P 

PROVIDER: S-EPMC12713827 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature