Circadian activity and sleep architecture in autism spectrum disorder mouse model with <i>Chd8</i> mutation.

ABSTRACT: Individuals with autism spectrum disorder (ASD) frequently experience sleep disturbances, including difficulties in sleep initiation, reduced total sleep time, and excessive daytime sleepiness. Among them, those carrying mutations in the CHD8, a high-penetrance ASD risk gene, often exhibit both core ASD symptoms and pronounced sleep abnormalities. However, detailed evaluations of sleep architecture and circadian activity in this population remain limited. In this study, we characterized the daily sleep patterns of Chd8 heterozygous knockout mice of both sexes, an established ASD model, using electroencephalography (EEG)/electromyography (EMG) recordings. Chd8 knockout mice exhibited reduced wakefulness and increased rapid eye movement (REM) sleep duration during the da

SUBMITTER: Yu J 

PROVIDER: S-EPMC12713839 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature