Investigation of causal effects of blood metabolites on insomnia and circadian rhythm sleep wake disorders.

ABSTRACT:

Background

Insomnia (IS) and circadian rhythm sleep-wake disorders (CRSWD) are complex disorders with limited and unsatisfactory treatment options that can even cause some side effects. By analyzing blood metabolites to reveal underlying biological processes, studies of sleep and the complex interactions between its influencing factors can be elucidated. Therefore, we hope to bring new hope for the treatment of these diseases through blood metabolites.

Aims

Investigating the causal link between blood metabolites and IS and CRSWD.

Methods

A genome-wide association study (GWAS) for 486 metabolites was used as the exposure, whereas two different GWAS datasets for sleep disorders were the outcome, and all datasets were obtained from publicly available databases. We employ

SUBMITTER: Lv Z 

PROVIDER: S-EPMC12713914 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature