Intrinsic persistent firing in CA1 encodes elapsed time across behaviorally relevant scales.

ABSTRACT: The ability to encode and maintain temporal relationships is crucial for learning, predicting, and forming episodic memories. While hippocampal time cells and entorhinal temporal context cells are well-established in vivo, it remains unclear whether single neurons can sustain representations of elapsed time over multi-second intervals, independent of synaptic drive. Here, using whole-cell patch-clamp recordings in rodent hippocampal CA1 slices under synaptic blockade, we show that following a brief current pulse, many neurons exhibit exponentially decaying firing rates with a broad distribution of time constants extending to tens of seconds. This indicates that single neurons possess intrinsic mechanisms capable of covering behaviorally relevant temporal scales. These results highli

SUBMITTER: Zomorodi S 

PROVIDER: S-EPMC12714023 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature