Brain Network Controllability and Its Regional Gene Expression Profile Associated With Suicidal Tendencies in Major Depressive Disorder Patients.

ABSTRACT: Suicidality is the most severe sign of major depressive disorder (MDD). However, network-wide structural dynamics alterations and transcriptional patterns in MDD patients with suicidality remain unclear. A total of 124 participants were recruited, including 31 MDD patients without suicidal ideation (MDDNSI), 34 MDD patients with suicidal ideation (MDDSI), 22 MDD patients with suicidal behavior (MDDSB), and 37 healthy controls (HCs). All participants completed diffusion tensor imaging scans and suicidal assessment. Network-based statistics (NBSs) were used to compare differences in structural connectivity, while average network controllability (ANC) reflecting brain state dynamics was measured based on suicidality-based circuits. Weighted gene coexpression network analysis (WGCNA) identifie

SUBMITTER: Liu X 

PROVIDER: S-EPMC12714167 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature