Integrated Multiomics Unravels Hedgehog (HH) Signaling Characteristics in Pancreatic Cancer (PC) and DCBLD2 Regulates HH Signaling to Drive PC Progression.

ABSTRACT: Hedgehog (HH) signaling plays a crucial role in cancer development. However, HH signaling-related molecular characteristics have not been comprehensively evaluated in pancreatic cancer (PC). This study dissected the characteristics of HH signaling in PC using integrated bulk and single-cell profiling. GSEA indicated that HH signaling is significantly enriched in PC tissue. Consensus clustering was utilized to classify PC samples into two HH signaling-related subtypes: HRGcluster A and HRGcluster B. In contrast with HRGcluster A, HRGcluster B has an earlier clinical stage, better outcome, less active level of HH signaling, higher infiltration level of CD8+ T cells and B cells, and a greater likelihood of benefiting from immunotherapy and gemcitabine chemotherapy. Moreover, an HH signaling-r

SUBMITTER: Zhang B 

PROVIDER: S-EPMC12714175 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature