Phenotypic stratification predicts the pace, but not the outcome, of continence recovery after radical prostatectomy.

ABSTRACT:

Background

Urinary incontinence (UI) is a common complication following radical prostatectomy (RP), with heterogeneous response to pelvic floor rehabilitation. Identifying patient subgroups with distinct recovery patterns may improve treatment planning.

Methods

We prospectively enrolled 182 men (mean age 66.1 ± 6.5 years) undergoing RP for localized prostate cancer. All participated in a standardized rehabilitation program. K-means clustering was applied to 11 baseline clinical variables, including urinary incontinence severity, pelvic floor function measures, and oncological risk characteristics, to identify distinct patient phenotypes. Continence was defined as pad test result ≤2 g and assessed at three time points. Statistical analyses included non-parametric tests, clust

SUBMITTER: Terek-Derszniak M 

PROVIDER: S-EPMC12714187 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature