Analysis of molecular mechanism of Chinese medicine Jinhong decoction (JHD) in synergistically treating sepsis and COVID-19 based on network pharmacology.

ABSTRACT: Sepsis and COVID-19 are the two mutually-reinforcing risk factors, whose interaction drastically increases mortality rate. Jinhong decoction (JHD) as a Chinese medicine exhibits clinical efficacy against them, but related action mechanism remains to be explored. To this end, using network pharmacology, this study screened active ingredients of JHD and their targets from TCMSP, HERB, PubChem and SwissTargetPrediction databases as well as the targets for these two diseases from DisGeNET, OMIM, Drugbank, TTD, and GeneCards. By intersecting drug and disease targets, we identified common targets and constructed a drug-ingredient-target network. GO and KEGG enrichment analyses revealed key target-related signaling pathways, and transcriptomics analysis further validated tissue distribution of th

SUBMITTER: Fan J 

PROVIDER: S-EPMC12714189 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature