OpenIDS2: A low-cost, 3D-printed, open-source platform for reproducible construction of DNA microarray synthesizers.

ABSTRACT: Oligonucleotide synthesis is a fundamental technology in various fields of life science, including synthetic biology, molecular diagnostics, and biotechnology. In this study, we present OpenIDS2, an open-source, second-generation inkjet-based DNA synthesizer designed to enable flexible and low-cost synthesis in laboratory settings. Built upon the original OpenIDS platform, OpenIDS2 reduces the overall device volume to approximately one-third, integrates all control electronics through a custom-designed printed circuit board (PCB), and improves operational stability and fabrication accessibility via a peristaltic pump-based bulk solution delivery system. Notably, most mechanical components are designed for 3D printing, allowing users to fabricate and assemble the system at low cost using wi

SUBMITTER: Kim J 

PROVIDER: S-EPMC12714190 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature